ID Number		1917
Study Type		In Vitro
Model		Meta analysis of ELF exposure and effects on micronuclei, chromosome aberrations, and DNA damage using in vitro systems
Details		Meta-analysis of 87 different reports on DNA damage, micronuclei, and chromosome aberrations published between 1990-2007. Studies were stratified based on frequency (above, equal to, or below standard power line frequencies of 50-60 Hz) and magnetic flux density (0.0-0.5 mT, >0.5-1.0 mT, >1.0-5.0mT, or > 5 mT). Occupational exposure was also defined using a simple job matrix(e.g., electric train drivers, power line inspectors, high-voltage substation workers). The authors report statistically significant effects for both single and double strand DNA breaks(p<0.001), chromosome aberrations(p<0.01), micronuclei(p<0.05), and sister chromatid exchanges(p<0.05). When cells were initiated with mutagens, there was an increased effect of ELF exposure on the promotion of micronuclei (p<0.001). As with the RF meta-analysis, the authors report a publication bias (p<0.001). The authors do indicate that in studies using exposure levels at or below the ICNIRP level, there was no statistically significant effect on the measured endpoints.
Findings		Effects
Status		Completed With Publication
Principal Investigator		Univeristy of Texas, USA - vijay@uthscsa.edu
Funding Agency		FGF, Germany
Country		UNITED STATES
References		Vijayalaxmi, et al. Int J Rad Biol, (2009) 85:196-213
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