ID Number		1998
Study Type		In Vitro
Model		1-100 Hz pulsed electric field exposure to endothelial cells and analysis of growth, NO production, and expression of ET-1
Details		Endothelial cells were exposed to pulsed electrical signals from 1 to 100 Hz at 25 mV for 6 hours. The authors report increased proliferation with exposures of 10-100 Hz, but decreased proliferation with stimulation below 10 Hz. Nitric oxide levels increased with stimulation from 20-100 Hz and the peak value of ET-1 (Endothelin-1, a potent endothelial-derived 21-amino-acid vasoconstrictor peptide) was increased with a peak at 100 Hz. The authors conclude pulsed electric fields may offer a mechanism to enhance endothelial cell and vascular function.
Findings		Effects
Status		Completed With Publication
Principal Investigator		Sichuan Univ, Chengdu China
Funding Agency		Nat'l Res Prog, China
Country		CHINA
References		Yue, A et al. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi., (2008) 25:694-698
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