ID Number		2103
Study Type		In Vitro
Model		50 Hz (ELF) exposure to cells in vitro and analysis of gene expression and enzyme activity.
Details		HaCaT human keratinocytes were exposed to 50 Hz PEMF and analyzed for expression of nitric oxide synthases (NOS) and cyclooxygenase-2 (COX-2), both demonstrated to be involved in the wound healing process. Exposure increased inducible NOS and endothelial NOS expression, increased NO production, decreased COX and PGE-2 levels, and increased AP-1 expression and cell proliferation. The authors suggest ELF exposure may be an effective therapeutic treatment to facilitate tissue regeneration.
Findings		Effects
Status		Completed With Publication
Principal Investigator		University "G. d'Annunzio", Chieti-Pescara, Italy
Funding Agency		Private/Instit.
Country		ITALY
References		Patruno, A et al. Br J Dermatol., (2010) 162:258-266 Patruno, A et al. Life Sci., (2015) 121:117-123 Patruno, A et al. Journal of Cellular Physiology., (2012) 227:2767-2774 Patruno, A et al. Int. J. Mol. Sci., (2020) 21:7284-
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