ID Number		2216
Study Type		In Vivo
Model		Studies of thyroid and mast cells of rats and humans exposed to electromagnetic fields.
Details		Wistar rats (n = 60) were exposed to 50 Hz (ELF) 4 hr/day at 100-300 microT either with or without daily oral doses of atrazine(an herbicide used in agriculture thought to have toxic side-effects in marine and other vertebrate species). Skin samples were isolated from treated rats and the number, density, and granule content of mast cells was determined. The authors report an increase in atrazine-only treated skin samples that did not show a dose response. The effect of EMF + atrazine was not significantly different than that of atrazine alone, suggesting no additional effect. AUTHORS' ABSTRACT: Rajkovic et al. 2010 (IEEE #6322): PURPOSE: The aim of this study was to examine the effect of extremely low-frequency magnetic fields (MF) and the endocrine-disrupting compound atrazine, each separately, on the thyroid gland of juvenile-peripubertal rats, and to investigate the possible synergistic effect of these two factors combined. MATERIALS AND METHODS: The study was performed on male Wistar rats from postnatal day 23-53. Animals were divided into six groups: (1) 4 h/day exposure to MF (50 Hz, 100-300 ¼T, 54-160 V/m), (2) 20 mg/kg of body weight (bw) of atrazine, (3) 200 mg/kg bw of atrazine, (4) MF with 20 mg/kg bw of atrazine (5) MF with 200 mg/kg bw of atrazine, and (6) control. RESULTS: Light and electron microscopic studies demonstrated no significant alterations in the thyroid structure between the treated groups and the control. Significant outcomes were found regarding the volume density of thyroid follicles and the connective tissue between the MF-exposed group when compared to both atrazine treatments and the combined treatments. The high dose of atrazine significantly affected the number of mast cells compared to the control. CONCLUSIONS: No synergistic effect of the MF and the endocrine-disrupting compound atrazine on the thyroid gland has been found. The specific histological alterations of the thyroid parenchyma observed in some treated groups require further investigation.
Findings		No Effects
Status		Completed With Publication
Principal Investigator		Karolinska Institute, Stockholm, Sweden - oerjan.hallberg@swipnet.se
Funding Agency		Private/Instit.
Country		SWEDEN
References		Rajkovic, V et al. Arch Environ Contam Toxicol., (2010) 59:334-341 Lemola, S et al. J Youth Adolesc., (2015) 44:405-418 Johansson, O et al. Journal of cutaneous pathology., (2001) 28:513-519
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