ID Number		2485
Study Type		Epidemiology
Model		Probabilistic simulation was used to estimate population attributable fractions and attributable cases of childhood leukaemia in the EU27.
Details		AUTHORS' ABSTRACT: Grellier, Ravazzani and Cardis 2014 (IEEE #5992): Over the last two decades residential exposure to extremely low frequency magnetic fields (ELF MF) has been associated with childhood leukaemia relatively consistently in epidemiological studies, though causality is still under investigation. We aimed to estimate the cases of childhood leukaemia that might be attributable to exposure to ELF MF in the European Union (EU27), if the associations seen in epidemiological studies were causal. We estimated distributions of ELF MF exposure using studies identified in the existing literature. Individual distributions of exposure were integrated using a probabilistic mixture distribution approach. Exposureresponse functionswere estimated from the most recently published pooled analysis of epidemiological data. Probabilistic simulation was used to estimate population attributable fractions (AFP) and attributable cases of childhood leukaemia in the EU27. By assigning the literature review-based exposure distribution to all EU27 countries, we estimated the total annual number of cases of leukaemia attributable to ELFMF at between ~50 (95% CIs:14, 132) and ~60 (95% CIs:-9, 610), depending on whether exposureresponse was modelled categorically or continuously, respectively, for a non-threshold effect. This corresponds to between ~1.5% and ~2.0% of all incident cases of childhood leukaemia occurring annually in the EU27. Considerable uncertainties are due to scarce data on exposure and the choice of exposureresponse model, demonstrating the importance of further research into better understanding mechanisms of the potential association between ELF MF exposure and childhood leukaemia and the need for improved monitoring of residential exposures to ELF MF in Europe.
Findings		Effects
Status		Completed With Publication
Principal Investigator
Funding Agency		?????
Country		SPAIN
References		Grellier , J et al. Environment International. , (2014) 62:55-63
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