ID Number		2510
Study Type		In Vivo
Model		Effects of ELF magnetic field (ELF-MF, 50 Hz, 0.5 mT) exposure on spontaneous and amphetamine-induced (1.5mg/kg, i.p.) locomotor and stereotypic activities in adult rats were examined by open field test for 2 h on exposure days 1, 3, and 7.
Details		AUTHORS' ABSTRACT: Janac et al. 2005 (IEEE #6110): The effects of chronic (7 days) exposure to an extremely low frequency magnetic field (ELF-MF, 50 Hz, 0.5 mT) on spontaneous and amphetamine-induced (1.5mg/kg, i.p.) locomotor and stereotypic activities in adult rats were examined by open field test for 2h on exposure days 1, 3, and 7. After 1 day of exposure to ELF-MF, the spontaneous locomotor activity was increased clearly at the first hour of observation and significantly at the second one as compared to the corresponding values in other series with ELF-MF and sham-exposed animals. After 7 days of exposure to ELF-MF, an amphetamine enhancing effect on the locomotor activity was significantly reduced at the second hour of observation as compared to that in 1-day- and sham-exposed rats treated with amphetamine. In contrast to the locomotor activity, the amphetamine-induced stereotypic behaviour in 7-day pre-exposed rats was significantly reduced at the first hour versus sham-exposed rats. While at the second hour of observation this effect was significant as compared to 1- and 3-day exposed animals (but not sham-exposed rats). Our results indicate that an extremely low frequency magnetic field is able to affect differently two types of behaviour, which are dependent on both the time course of exposure and the imbalance in the brain mediatory systems.
Findings		Effects
Status		Completed With Publication
Principal Investigator		Institute for Biol. Res. Siniaa Stankovi, Serbi
Funding Agency		?????
Country		SERBIA
References		Janac, B et al. Brain Res Bull., (2005) 67:498-503 Jelenkovic, A et al. Brain Res. Bull., (2006) 68:355-360
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