ID Number		2614
Study Type		In Vivo
Model		Study of effects of melatonin and omega-3 on neuronal damage in the hippocampus of rats exposed to 900 MHz.
Details		AUTHORS' ABSTRACT: Erdem Koc et al. 2016 (IEEE #6435): PURPOSE: Adverse effects on human health caused by electromagnetic fields (EMF) associated with the use of mobile phones, particularly among young people, are increasing all the time. The potential deleterious effects of EMF exposure resulting from mobile phones being used in close proximity to the brain require particular evaluation. However, only a limited number of studies have investigated the effects of prenatal exposure to EMF in the development of the pyramidal cells using melatonin (MEL) and omega-3 (É-3). MATERIALS AND METHODS: We established seven groups of pregnant rats consisting of three animals each; control (CONT), SHAM, EMF, EMF + MEL, MEL, EMF + É-3 and É-3 alone. The rats in the EMF, EMF + MEL, EMF + É-3 groups were exposed to 900 MHz EMF for 60 min/day in an exposure tube during the gestation period. The CONT, MEL and É-3 group rats were not placed inside the exposure tube or exposed to EMF during the study period. After delivery, only spontaneously delivered male rat pups were selected for the establishment of further groups. Each group of offspring consisted of six animals. The optical fractionator technique was used to determine total pyramidal neuron numbers in the rat hippocampal region. RESULTS: The total number of pyramidal cells in the cornu ammonis (CA) in the EMF group was significantly lower than in the CONT, SHAM, EMF + MEL, and EMF + É-3 groups. No significant difference was observed between the EMF, MEL and É-3 groups. No difference was also observed between any groups in terms of rats' body or brain weights. CONCLUSION: MEL and É-3 can protect the cell against neuronal damage in the hippocampus induced by 900 MHz EMF. However, further studies are now needed to evaluate the chronic effects of 900 MHz EMF on the brain in the prenatal period. AUTHOR' ABSTRACT: Kocaman et al. 2017 (IEEE #6898}: The aim of this study was to investigate the harmful effects of exposure to 900-megahertz (MHz) electromagnetic fields (EMF) and the protective effects of omega-3 (Omg-3) against EMF in the rat adrenal gland. Eighteen Wistar albino rats were randomly assigned into three groups, control (Cont), EMF, and EMF + Omg-3. The EMF and EMF + Omg-3 groups both consisted of six rats exposed to an EMF of 900 MHz for 60 min/day for 15 days. No procedure was applied to the six rats in the Cont group. At the end of the experiment, all rats were sacrificed, and the mean volumes of the cortex and medulla of the adrenal gland were estimated using a stereological counting technique. The stereological results showed that the mean volume of the adrenal gland increased significantly in the EMF-exposed groups compared to the Cont group. Additionally, the mean volume of the adrenal gland was significantly lower in the EMF + Omg-3 group compared to the EMF group. We suggest that Omg-3 therapy aimed at suppressing the effects of EMF may prove a safe alternative for animals, whether or not they are exposed to EMF.
Findings		Effects
Status		Completed With Publication
Principal Investigator		Ondokuz May1s Univ, Samsun, Turkey
Funding Agency		Turkey, Ondokuz Mayis Univ
Country		TURKEY
References		Erdem Koc, G et al. International Journal of Radiation Biology. , (2016) 92:590-595 Kocaman, A et al. Journal of Microscopy and Ultrastructure., (2017) 5:185-190 Kivrak, EG et al. J Microsc Ultrastruct., (2017) 5:167-176
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