ID Number		2644
Study Type		In Vivo
Model		The effects of a) ELF-EMF (50 Hz, 3 mT) on the lifespan, locomotion, heat shock response (HSR), and oxidative stress (OS) on flies and b) RF (3.5 GHz) on Drosophila Melan0gaster (fruit fly).
Details		AUTHORS' ABSTRACT: Zhang et al. 2016 (IEEE #6515): Temperature is an important factor in research on the biological effects of extremely low-frequency electromagnetic field (ELF-EMF), but interactions between ELF-EMF and temperature remain unknown. The effects of ELF-EMF (50 Hz, 3 mT) on the lifespan, locomotion, heat shock response (HSR), and oxidative stress (OS) of Canton-Special (CS) andmutant w1118 flies were investigated at 25°C and 35°C (thermal stress). Results showed that thermal stress accelerated the death rates of CS and w1118 flies, shortened their lifespan, and influenced their locomotion rhythm and activity. The upregulated expression levels of heat shock protein (HSP) 22, HSP26, and HSP70 indicated that HSR was enhanced. Thermal stress-inducedOS response increased malondialdehyde content, enhanced superoxide dismutase activity, and decreased reactive oxygen species level. The effects of thermal stress on the death rates, lifespan, locomotion, and HSP gene expression of flies, especially w1118 line, were also enhanced by ELF-EMF. In conclusion, thermal stress weakened the physiological function and promoted the HSR and OS of flies. ELF-EMF aggravated damages and enhanced thermal stress-induced HSP and OS response. Therefore, thermal stress and ELF-EMF elicited a synergistic effect.
Findings		Effects
Status		Completed With Publication
Principal Investigator		Chinese Academy of Sciences, Xiamen, P. R. China,
Funding Agency		?????
Country		CHINA
References		Zhang, Y et al. PLoS ONE., (2016) 11(9):e0162675-doi:10.1371/journal.pone.0162675 Wang, Y et al. Environmental Pollution., (2021) 283:117087- Wang, Y et al. Environmental Pollution., (2022) 294:118646-
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