ID Number		390
Study Type		In Vivo
Model		900 MHz (GSM) exposure to mice and analysis of DNA damage and micronuclei (MX-initiated bioassay)
Details		Wistar rats exposed to 900 MHz (GSM) for 2 years at 0.3 (range 0.17 - 0.43) or 0.9 (range 0.52 - 1.28) W/kg (whole body avg) following 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (also called MX) administration (as described previously (Komulainen et al., 1997, J. Natl. Cancer Inst. 89:848-856). Blood samples were taken at periods over the course of the 2 year study and analyzed for micronuclei. At the termination of the study, brain and liver tissue was taken for analysis of DNA breaks via comet assay. The authors report no increase of any endpoint due to RF exposure, but do report significant decreases in DNA damage with low (0.3 W/kg) dose exposure, and for MN at all exposure levels. At 24 months, however, no significant effects remained.
Findings		No Effects
Status		Completed With Publication
Principal Investigator		VITO, Belgium - verschal@vitoosf1.vito.be
Funding Agency		EU, CEMFEC, EU 5th Framework, Europe
Country		BELGIUM
References		Verschaeve, L et al. Radiation Research, (2006) 165:598-607
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