|
EMF Study
(Database last updated on Mar 27, 2024)
ID Number |
|
630 |
Study Type |
|
In Vitro |
Model |
|
1800 MHz(GSM) exposure to mouse primary astrocytes + pig brain capillary endothelial cells and analysis of sucrose permeability (in vitro BBB model) |
Details |
|
Astrocytes from neonatal rat brain and porcine brain capillary endothelial cells were co-cultured to simulate brain and examine the effects of RF on blood brain barrier. Cultures were exposed to 1.8 GHz (GSM) RF for 4 days at an average SAR of 0.3 W/kg (0.46 W/kg peak) in a rectangular waveguide. During the exposure period, permeability was examined at various time points during the 4 day exposure period by morphological analysis, electron microscopy (close apposition of cells, lack of intracellular clefts), immunocytochemistry (zona occludens protein leakage), and 14C-sucrose leakage. The authors report that exposure significantly increased the permeability of 14C-sucrose across the endothelial cell boundry (using data from 16 exposed and 9 control cultures; p < 0.001) Infra red thermometry of the culture samples was used to verify that the temperature increases due to exposure were not significant. |
Findings |
|
Effects |
Status |
|
Completed With Publication |
Principal Investigator |
|
University of Bordeaux, France - b.veyret@piom.u-bordeaux.fr
|
Funding Agency |
|
CoMoBio, France
|
Country |
|
GERMANY |
References |
|
Schirmacher, A et al. Bioelectromagnetics, (2000) 21:338-345
|
Comments |
|
|
Return
|