ID Number		638
Study Type		In Vivo
Model		27 MHz (CW) exposure to pregnant rats and analysis of teratogenicity and survival of offspring
Details		Sprague Dawley rats (pregnant dams) were exposed to 27.12 MHz (CW) RF for 10 to 40 minutes at SARs of 10.8 W/Kg on gestation day 9 in restraining tubes until core body temperature reached specific values between 41.0 - 43.0°C. On gestation day 20 rats were killed and fetuses examined. The threshold temperature for prenatal mortality was ~ 41.7°C and the threshold temperature for birth defects was ~41.5°C. Fetal length was reduced at 42.5 and 43.0°C and fetal weight was reduced at 43.0°C. Earlier studies by the group clearly showed 27 MHz RF hyperthermic exposures at ~ 11 W/kg for ~ 30 minutes (sufficient to increase core body temperature of the dam to 43°C) on gestation days 7 - 15 lead to various fetal malformations as well as a reduction in offspring number and health. In addition, 27 MHz exposures resulting in core temperature increases of 41 - 42°C could also lead to teratogenic effects if the time of exposure was increased. The authors conclude that a high threshold temperature is necessary for lethal and teratogenic effects.
Findings		Effects (only at thermal levels)
Status		Completed With Publication
Principal Investigator		NIOSH, USA
Funding Agency		NIOSH, USA
Country		UNITED STATES
References		Lary, JM et al. Bioelectromagnetics, (1986) 7:141-149 Lary, JM et al. Bioelectromagnetics, (1983) 4:249-255 Lary, JM et al. Scand. J. Work Environ. Health, (1983) 9:120-127 Lary, JM et al. Teratology, (1982) 26:299-309
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