ID Number		944
Study Type		In Vivo
Model		900, 1800 MHz (GSM) exposure to B6C3F1 mice and analysis of micronuclei
Details		B6C3F1 mice (n = 20 per exposure group, half males half females) were exposed to 900 and 1800 MHz (GSM) RF 2 hours/day for either 1 or 6 weeks at whole body SARs of 0, 3.7, 11, and 33 W/kg (1 week study) or 0, 2.8, 8.3, and 25 W/kg (6 week study). RF signal included a cocktail of all components commonly existing in a standard mobile phone transmission (i.e., low-frequency amplitude modulation resulting from speaking, delayed [DTx] transmissions associated with listening, variations due to handovers and power control). Mice were tube-restrained and radially positioned in a ferris-wheel system with a central antenna. Dosimetry and numerical modeling revealed generally homogeneous exposure. Following exposure, mice were examined for micronuclei in peripheral blood and bone marrow erythrocytes as well as in keratinocytes and spleen lymphocytes. The authors report no effects of RF exposure on clinical abnormalities or micronuclei in any of the cell types examined, and further no thermal effects even at the highest exposure levels. As a follow-on to the above study and as part of a larger 2-yr bioassay (Tillmann 2007), B6C3F1 mice were exposed to 900 MHz (GSM) at 0.4, 1.3, or 4 W/kg or 1800 MHz (GSM) at 0.33, 1.0, and 3.0 W/kg. Exposures ran for 2 hrs/day, 5 days/wk, for 2 yrs. The authors report no effects on micronuclei formation or chromosome abnormalities in peripheral blood samples from mice analyzed at the end of the 2-yr bioassay.
Findings		No Effects
Status		Completed With Publication
Principal Investigator		Fraunhofer ITEM, Hannover, Germany - dasenbrock@ita.fhg.de
Funding Agency		EU, MMF, CTIA, USA, GSM Association
Country		GERMANY
References		Ziemann, C et al. Int J Radiat Biol., (2009) 85:454-464 Gorlitz, BD et al. Radiation Research, (2005) 164:431-439
Comments		Part of CTIA CRADA studies to validate previous findings of micronuclei formation following microwave exposure